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KMID : 0895820070170040055
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Journal of Oriental Rehabilitation Medicine
2007 Volume.17 No. 4 p.55 ~ p.73
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The Effects of Jeho-tang(Tihutang) and Ganoderma Lucidum Extract on the Recovery of Fatigue in High Intensity Exercise Rats
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Park Ji-Hun
Choi Jin-Bong
Shin Mi-Suk
Kim Sun-Jong
Park Jung-Hyun
Lee Jung-Ho
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Abstract
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Objectives :This study was designed to evaluate the effects of Jeho-tang(Tihutang) and Ganoderma Lucidum extract on the recovery of fatigue induced by treadmill exercise in rats.
Methods :The rat subjects were divided into 4 groups : Normal, Control with treadmill exercise under 70% max(VO2max) intensity, Experimental Ⅰ(Ex Ⅰ) taken with Jeho-tang during treadmill exercise and Experimental Ⅱ(Ex Ⅱ) taken with Ganoderma Lucidum extract during treadmill exercise. All the serum samples collected by heart puncture were used to measure biomechanical factors such as lactate dehydrogenase(LDH), ammonia, inorganic phosphate, creatine kinase(CK), glucose, lactate, triglycerides(TG), high-density lipoprotein(HDL), low-density lipoprotein(LDL) and total cholesterol(TC). Besides, glycogen concentration and Heat shock protein 70(HSP70) by western blotting were measured. Histopathological changes in liver, kidney and muscle were investigated.
Results :1. LDH, ammonia, inorganic phosphate and lactate were significantly decreased in the experimental groups as compared with control group(p<0.05). 2. TC and LDL were significantly decreased in the Ex Ⅰ and Ex Ⅱ as compared with control group(p<0.05). 3. The HSP70 expression was increased in all the groups, especially significant in Ex Ⅱ.
Conclusion :According to the above results, Jeho-tang(Tihutang) and Ganoderma Lucidum extract can recover the fatigue after high intensity exercise. If Jeho-tang (Tihutang) and Ganoderma Lucidum extract can be more useful as ergogenic aids, further studies about their underlying mechanism may be needed.
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KEYWORD
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Jeho-tang(Tihutang), Ganoderma Lucidum, Treadmill exercise, Ergogenic aid
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